Deep Cholesterol Binding Sites on Mammalian Membrane Proteins

Transporters

[Letters refer to subunits as given in the PDB file, followed by the TM helix number:Units of E, kcals/mol with molar concentration units].

E Donor Acceptor Local Residues (within 3 Å of a cholesterol -OH group)
ATPases
Calcium ATPase [B sarcolipin; C phospholamban]
E1 with bound Ca and AMPPCP, rabbit  1vfp
-6.1 Chl OH Ser942 [9] OG Cys938 [9] Met941 [9] Ser942 [9]
-5.9 Chl OH Leu797 [6] O Leu797 [6] Leu802 [6] Ser940  [9]
E1 with bound Ca, rabbit  1su4
-6.4 Chl OH Ser942 [9] OG Cys938 [9] Ser942 [9]
-6.2 Chl OH Met909 [8] O Thr906 [8] Met909 [8] Cys910 [8]
-5.8 Gly979 [10] N Chl O Leu975 [10] Gly979 [10]
E1 with bound Ca, rabbit, 2c9m
-7.0 Chl OH Thr906 [8] OG1 Thr906 [8] Cys910 [8]
Thr906 [8] OG1 Chl OH
-6.1 Chl OH Gly842 [7] O Gly842 [7]
Structure in ultrathin crystals, rabbit, 3j7t
-6.4 Chl OH Ser942 [9] OG Cys938 [9] Ser942 [9]
E1 Mg bound state with TNPAMP, rabbit, 3w5b
-6.3 Chl OH Ser942 [9] OG Cys938 [9] Ser942 [9]
Ca bound phosphorylated form with AMPPN, rabbit 3ba6
-7.0 Chl OH Leu797 [6] O Leu797 [6] Val798 [6] Ser940 [9]
-6.4 Chl OH Ala839 [7] O Met838 [7] Ala839 [7] Gly842 [7] Tyr843 [7]
-6.4 Chl OH Ser942 [9] OG Cys938 [9] Ser942 [9]
-6.3 Chl OH Met909 [8] O Thr906 [8] Met909 [8] Cys910 [8]
Chl OH Thr906 [8] O
E1 with bound Ca and AMPPCP, rabbit  1t5s
-6.9 Chl OH Met909 [8] O Thr906 [8] Met909 [8] Cys910 [8]
Chl OH Thr906 [8] O
E1 state with bound Ca and AMPPCP, rabbit, 4xou
-7.3 Chl OH Leu797 [6] O Leu797 [6] Val798 [6] Ser940 [9]
-6.9 Chl OH Ser940 [9] OG Leu797 [6] Val798 [6] Ser940 [9]
-6.4 Chl OH Ala839 [7] O Met838 [7] Ala839 [7] Gly842 [7] Tyr843 [7]
Tyr843 [7] N Chl OH
E1 Ca bound state mutant with AMPPCP, rabbit, 4nab
None
E2 State with phosphate, rabbit, 3w5d
-6.7 Chl OH Ser942 [9] OG Cys938 [9] Met941 [9] Ser942 [9]
E2 state, and thapsigargin, rabbit  1iwo
-6.7 Chl OH Tyr295 [4] O Tyr295 [4]
E2 thapsigargin compex, rabbit, 5xab
-6.3 Chl OH Ser942 [9] OG Cys938 [9] Ser942 [9]
-6.2 Chl OH Tyr295 [4] O Tyr295 [4]
E2 state, Ca free with thapsigargin, rabbit, 2c8l
-6.6 Cys910 [8] SG Chl OH Thr906 [8] Cys910 [8]
-6.2 Chl OH Tyr295 [4] O Tyr295 [4]
With bound thapsigargin, rabbit, 2ear
-7.2 Chl OH Cys268 [3] O Cys268 [3] Trp272 [3]
Trp272 [3] N Chl OH
-6.3 Trp794 [6] N Chl OH Val790 [6] Trp794 [6]
E2 state  and magnesium fluoride rabbit 1wpg
5.7 Trp794 [6] N Chl O Val790 [6] Leu793 [6] Trp794 [6]
E2 state  and thapsigargin and aluminium fluoride rabbit 1xp5
-6.0 Chl OH Tyr295 [4] O Tyr295 [4]
E2 state, Ca free with thapsigargin and AMPPCP, rabbit, 2c8k
-6.3 Cys910 [8] SG Chl OH Thr906 [8] Cys910 [8]
E2 state  and AMPPN and  aluminium fluoride rabbit 3b9r
-6.5 Chl OH Pro91 [2] O Ala69 [1] Pro91 [2] Leu95 [2]
E2-Pi  state  and beryllium fluoride rabbit 3b9b
None
With bound BHQ and thapsigargin, rabbit 2agv
None
With bound  thapsigargin derivative, rabbit 2by4
-7.4 Chl OH Val790 [6] O Val790 [6] Leu793 [6] Trp794 [6]
-6.4 Chl OH Leu975 [10] O Leu975 [10] Pro976 [10] Gly979 [10]
E2 Ca free state with dibutanoyl thapsigargin, 2yfy
-6.7 Chl OH Ser942 [9] OG Cys938 [9] Met941 [9] Ser942 [9]
With bound  thapsigargin and AMPPCP, rabbit 2c88
-6.6 Chl OH Tyr295 [4] O Tyr295 [4] Ala299 [4]
-6.3 Chl OH Gly842 [7] O Ala839 [7] Gly842 [7] Tyr843 [7]
-6.2 Cys910 [8] SG Chl O Thr906 [8] Met909 [8] Cys910 [8]
With bound CPA and thapsigargin, rabbit, 2eat
-6.2 Chl OH Pro91 [2] O Ala69 [1] Pro91 [2]
-6 Chl OH Leu266 [3] O Leu266 [3] Ile267 [3]
-5.7 Chl OH Leu793 [6] O Leu793 [6] Trp794 [6]
With bound CPA and curcumin, rabbit, 2eau
None
With bound cyclopiazonic acid and aluminium fluoride, rabbit 2o9j
-6.8 Chl OH Val790 [6] O Val790 [6] Leu793 [6] Trp794 [6]
-5.9 Cys910 [8] SG Chl O Thr906 [8] Cys910 [8]
-5.6 Chl OH Ala270 [3] O Ala270 [3] Leu273 [3]
Chl OH Leu273 [3] O
With bound cyclopiazonic acid and ADP, rabbit, 2oao
-7.2 Chl OH Val790 [6] O Val790 [6] Trp794 [6]
-5.9 Chl OH Gly842 [7] O Ala839 [7] Gly842 [7] Tyr843 [7]
E2-vandate complex with thapsigargin and TNP-AMPPCP, rabbit, 5a3q 
-6.1 Chl OH Cys268 [3] O Cys268 [3] Trp272 [3]
Trp272 [3] N Chl OH
E2-vanadate complex with thapsigargin and TNP-ATPP, rabbit, 5a3s
-5.9 Chl OH Tyr295 [4] O Tyr295 [4]
-5.7 Cys70 [1] N Chl OH Leu66 [1] Cys70 [1]
-5.7 Chl OH Cys268 [3] O Cys268 [3] Trp272 [3]
E2-BeF3 complex with TNP-AMPPCP, rabbit, 5a3r
-6.6 Chl OH Ile264 [3] O Ile264 [3] Ser265 [3]
Chl OH Ser265 [3] OG
-6.0 Chl OH Ala306 [4] O Ala306 [4]
-5.9 Chl OH Ala69 [1] O Ala69 [1] Pro91 [2]
E1-Ca bound with lipid, rabbit, 5xa7
-6.4 Chl OH Ser942 [9] OG Cys938 [9] Ser942 [9]
-6.1 Chl OH Met909 [8] O Met909 [8] Leu913 [8]
-6.0 Gly979 [10] N Chl OH Leu975 [10] Pro976 [10] Gly979 [10]
E1-AlF4 complex with Ca and ADP, rabbit, 5xa8
-6.4 Chl OH Leu797 [6] O Leu797 [6] Val798 [6] Ser940 [9]
Chl OH Ser940 [9] OG
E2-AlF4 complex with thapsigargin, , rabbit, 5xa9
-6.9 Chl OH Val790 [6] O Val790 [6] Trp794 [6]
Trp794 [6] N Chl OH
E2-AlF4 complex with thapsigargin, different crystal form, rabbit, 5xaa
-6.7 Chl OH Cys268 [3] O Cys268 [3] Tyr295 [4]
Chl OH Tyr295 [4] OH
-6.4 Chl OH Val790 [6] O Val790 [6] Leu793 [6] Trp794 [6]
-6.1 Chl OH Pro91 [2] O Ala69 [1] Pro91 [2] Ile94 [2]
-5.9 Chl OH Pro976 [10] O Leu975 [10] Pro976 [10] Ile978 [10] Gly979 [10]
Gly979 [10] N Chl OH
With bound tetrahydrocarbazole and TNP-ATP, rabbit, 5ncq
None
E1 with bound Ca and sarcolipin, rabbit 4h1w
-6.9 Chl OH Thr18 [B] OG1 Val14 [B] Thr18 [B]
-6.2 Chl OH Thr18 [B] OG1 Leu96 [2] Ala100 [2] Thr18 [B]
-6.2 Chl OH Cys268 [3] O Cys268 [3] Val269 [3]
With sarcolipin  and magnesium in E1 state, rabbit 3w5a
-6.1 Chl OH Cys268 [3] O Cys268 [3] Val269 [3]
-6.0 Gly979 [10] N Chl O Leu975 [10] Gly979 [10]
With two bound phospholamban, rabbit 4kyt
7.0 Chl OH Ile33 [C] O Ile33 [C] Asn34 [C]
-6.3 Chl OH Ser974 [10] OG Thr906 [8] Cys910 [8] Ser974 [10]
Cys910 [8] SG Chl O
SERCA pig heart, 5mpm
None
Na,K- ATPases [A, alpha subunit; B, β1 subunit; G, γ subunit]
Pig kidney, 3b8e
-7.0 Chl OH Leu46 [B] O Tyr43 [B] Leu46 [B] Ala47 [B]
-6.6 Chl OH Ser298 [A 3] OG Phe294 [A 3] Ser298 [A 3]
-6.5 Chl OH Gly806 [A 6] O Gly806 [A 6] Thr807 [A 6] Val810 [A 6]
-6.4 Chl OH Leu36 [G] O Leu36 [G]
-6.4 Chl OH Glu953 [A 9] OE2 Glu953 [A 9]
-6.3 Chl OH Ala101 [A 1] O Trp98 [A 1] Ala101 [A 1] Ile102 [A 1]
Pig kidney with bound Na, pre-E1P state without oligomycin, 3wgu
-8.0 Chl OH Ser988 [A 10] OG Ala925 [A 8] Ser988 [A 10] Leu989 [A 10]
-7.2 Chl OH Glu953 [A 9] OE1 Glu953 [A 9] Leu957 [A 9]
-7.1 Chl OH Gly806 [A 6] O Leu805 [A 6] Gly806 [A 6] Met809 [A 6] Val810 [A 6]
Chl OH Leu805 [A 6] O
Pig kidney with bound Na, pre-E1P state with oligomycin, 3wgv
-6.8 Chl OH Gly806 [A 6] O Gly806 [A 6] Glu954 [A 9]
-6.7 Chl OH Gly806 [A 6] O Leu805 [A 6] Gly806 [A 6] Val810 [A 6]
Chl OH Leu805 [A 6] O
-6.5 Chl OH Glu953 [A 9] OE1 Glu953 [A 9]
Pig kidney with bound Rb (K analogue), 3kdp
-7.1 Chl OH Leu36 [G] O Phe33 [G] Leu36 [G]
Chl OH Phe33 [G] O
-6.9 Thr955 [A 9] OG1 Chl O Trp924 [A 8] Thr955 [A 9]
-6.8 Thr955 [A 9] OG1 Chl O Leu951 [A 9] Phe952 [A 9] Thr955 [A 9]
-6.6 Chl OH Gly806 [A 6] O Leu805 [A 6] Gly806 [A 6]
Chl OH Leu805 [A 6] O
-6.4 Ala925 [A 8] N Chl O Val921 [A 8] Trp924 [A 8] Ala925 [A 8] Ser988 [A 10]
Chl OH Ser988 [A 10] OG
-6.3 Chl OH Glu953 [A 9] OE2 Gly806 [A 6] Glu953 [A 9]
Chl OH Gly806 [A 6] O
Pig kidney phosphorylated form with bufalin, 4res
-7.9 Thr955 [A 9] OG1 Chl O Trp924 [A 8] Leu951 [A 9] Thr955 [A 9]
-7.4 Chl OH Gly848 [A 7] O Tyr847 [A 7 Gly848 [A 7] Tyr43 [B]
Chl OH Tyr847 [A 7] O
Tyr43 [B] OH Chl O
Pig kidney phosphorylated form with ouabain, 4hyt
-6.6 Ala925 [A 8] N Chl O Val921 [A 8] Trp924 [A 8] Ala925 [A 8]
-6.5 Chl OH Gly848 [A 7] O Tyr847 [A 7] Gly848 [A 7] Tyr43 [B]
Chl OH Tyr43  [B] OH
Chl OH Tyr847 [A 7] O
Tyr43 [B] OH Chl O
Shark, 2zxe
-8.1 Chl OH Thr814 [A 6] O Gly813 [A 6] Thr814 [A 6] Met816 [A 6] Val817[A6] Pro818[A6]
-6.9 Chl OH Ser995 [A 10] OG Ser995 [A 10] Leu996 [A 10]
-6.6 Chl OH Glu960 [A 9] OE1 Glu960 [A 9]
-6.3 Chl OH Thr138 [A 2] OG1 Val134 [A 2] Ser137 [A 2] Thr138 [A 2]
Shark complex with ouabain, 3a3y
-7.6 Chl OH Ser995 [A 10] OG Ser995 [A 10] Leu996 [A 10]
-7.1 Chl OH Leu41 [B] O Tyr40 [B] Leu41 [B] Gly45 [B]
-7.1 Chl OH Ile327 [A 4] O Ala299 [A 3] Ile327 [A 4]
-6.9 Ala932 [A 8] N Chl O Val928 [A 8] Trp931 [A 8] Ala932 [A 8] Ser995 [A 10]
Shark with Tl substitution, 5avr
-8.1 Chl OH Ser995 [A 10] OG Ser995 [A 10] Leu996 [A 10]
Shark with Rb substitution, 5aw4
-7.6 Chl OH Ser995 [A 10] OG Ser995 [A 10] Leu996 [A 10]
-6.8 Chl OH Ser995 [A 10] OG Ala932 [A 8] Ser995 [A 10] Leu996 [A 10]
Solute Carrier (SLC) Transporter Superfamily
EAAT1 excitatory amino acid transporter (SLC1), mutant, bound to  L-Asp, human, 5llu
-5.9 Chl OH Trp267 [5] O Trp267 [5] Tyr268 [5] Pro270 [5] Leu271 [5]
GLUT1 glucose transporter (SLC2), mutant, human, 4pyp
None
GLUT1 glucose transporter (SLC2), bound to cytocholasin, human, 5eqi
-7.1 Chl OH Ser73 [2] OG Ser73 [2] Trp412 [11]
GLUT1 glucose transporter (SLC2), bound to GLUT-i1 inhibitor, human, 5eqg
-6.6 Chl OH Ser73 [2] OG Ser73 [2] Trp412 [11]
GLUT1 glucose transporter (SLC2), bound to GLUT-i2 inhibitor, human, 5eqh
-6.6 Chl OH Ser73 [2] OG Ser73 [2] Trp412 [11]
GLUT3 glucose transporter (SLC2), mutant, bound to D-glucose, outward facing form, human, 4zw9
-6.0 Chl OH Thr103 [3] OG1 Leu99 [3] Val102 [3] Thr103 [3]
-5.8 Chl OH Thr441 [12] OG1 Gly437 [12] Ile440 [12] Thr441 [12]
GLUT3 glucose transporter (SLC2), mutant, bound to maltose, outward facing form, human, 4zwb
-5.9 Chl OH Thr103 [3] OG1 Leu99 [3] Thr103 [3]
-5.9 Chl OH Thr441 [12] OG1 Gly437 [12] Ile440 [12] Thr441 [12]
GLUT3 glucose transporter (SLC2), mutant, bound to D-glucose, outward facing form, human, 4zwc
-5.7 Chl OH Thr103 [3] OG1 Leu99 [3] Val102 [3] Thr103 [3]
-5.5 Chl OH Thr441 [12] OG1 Gly437 [12] Phe438 [12] Thr441 [12]
GLUT5 fructose transporter (SLC2), open-inward facing form, bovine, 4yb9
-7.2 Chl OH Thr452 [12] OG1 Ile448 [12] Thr452 [12]
-7 Chl OH Ser422 [11] OG Val418 [11] Ser422 [11]
-6.4 Chl OH Thr354 [9] OG1 Thr354 [9] Ala355 [9]
GLUT5 fructose transporter (SLC2), open-outward facing form [renumbered to matxh 4yb9], rat, 4ybq
-6.6 Chl OH Ser422 [11] OG Val418 [11] Ser422 [11]
Erythrocyte Band 3 anion exchange (SLC4), human, 4yzf
None
DAT Dopamine transporter (SLC6), bound to antidepressant, Drosophila, 4m48
None
DAT Dopamine transporter (SLC6),bound to dopamine, Drosophila, 4xp1
-7.8 Chl OH Ser453 [9] OG Ala449 [9] Phe452 [9] Ser453 [9]
-6.7 Chl OH Thr535 [11] OG1 Thr535 [11]
DAT Dopamine transporter (SLC6),bound to D-amphetamine, Drosophila, 4xp9
-8.1 Chl OH Ser412 [8]  OG Ala408 [8] Ser412 [8]
DAT Dopamine transporter (SLC6),bound to methamphetamine, Drosophila, 4xp6
-7.6 Chl OH Ser453 [9] OG Ala449 [9] Phe452 [9] Ser453 [9]
-6.9 Chl OH Thr535 [11] OG1 Leu484 [10] Thr535  [11]
DAT Dopamine transporter (SLC6),bound to 3,4-dichlorophenethylamine, Drosophila, 4xpa
-8 Chl OH Ser453 [9] OG Ala449 [9] Phe452 [9] Ser453 [9]
DAT Dopamine transporter (SLC6),bound to cocaine, Drosophila, 4xp4
-7.4 Chl OH Ser453 [9] OG Ala449 [9] Ser453 [9]
DAT Dopamine transporter (SLC6),bound to cocaine analogue, Drosophila, 4xp5
-6.9 Chl OH Ser453 [9] OG Ala449 [9] Phe452 [9] Ser453 [9]
DAT Dopamine transporter (SLC6),mutant, bound to cocaine, Drosophila, 4xpb
-6.5 Chl OH Ser566 [12] OG Cys562 [12] Ile563 [12] Ser566 [12]
-6.4 Chl OH Ser453 [9] OG Ala449 [9] Phe452 [9] Ser453 [9]
DAT Dopamine transporter (SLC6),mutant, bound to RTI55, Drosophila, 4xpf
-7.4 Chl OH Thr355 [7] OG1 Ile351 [7] Ala354 [7] Thr355 [7]
DAT Dopamine transporter (SLC6),mutant, bound to beta-CFT,  Drosophila, 4xpg
-7.8 Chl OH Ser453 [9] OG Ala449 [9] Ser453 [9]
DAT Dopamine transporter (SLC6),mutant, bound to 3,4-dichlorophenethylamine,  Drosophila, 4xph
-7.7 Chl OH Ser453 [9] OG Ala449 [9] Ser453 [9]
-6.9 Chl OH Ser482 [10] PG Ser482 [10] Ala564 [12] Val568 [12]
DAT Dopamine transporter (SLC6),mutant with 3,4-dichlorophenethylamine,  Drosophila, 4xpt
-7.5 Chl OH Ser453 [9] OG Ala449 [9] Phe452 [9] Ser453 [9]
DAT Dopamine transporter (SLC6),bound to nisoxetine, Drosophila, 4xnu
-6.9 Chl OH Ser453 [9] OG Ala449 [9] Ser453 [9]
DAT Dopamine transporter (SLC6),bound to reboxetine, Drosophila, 4xnx
-7.5 Chl OH Ser453 [9] OG Ala449 [9] Ser453 [9]
Serotonin transporter (SLC6), bound to paroxetine, human, 5i6x
-8.5 Chl OH Thr264 [4] OG1 Met260 [4] Thr264 [4]
-7.7 Chl OH Thr503 [10] OG1 Pro499 [10] Ala500 [10] Thr503 [10]
-7.1 Chl OH Thr433 [8] OG1 Leu429 [8] Thr433 [8]
-6.9 Chl OH Ser584 [12] O Ile167 [3] Tyr171 [3] Ser584 [12]
Chl OH Tyr171 [3] OH
Serotonin transporter (SLC6), mutant, bound to s-citalopram, human, 5i71
-9.1 Chl OH Phe263 [4] O Met260 [4] Phe263 [4] Thr264 [4]
Chl OH Thr264 [4] OG1
-7.5 Chl OH Thr371 [7] OG1 Val367 [7] Met370 [7] Thr371 [7]
Serotonin transporter (SLC6), mutant, bound to s-citalopram at more sites, human, 5i73
-9.2 Chl OH Phe263 [4] O Met260 [4] Phe263 [4] Thr264 [4]
-8.0 Chl OH Phe263 [4] O Met260 [4] Phe263 [4] Thr264 [4]
Chl OH Thr264 [4] OG1
-6.3 Chl OH Phe548 [12] O Leu547 [12] Phe548 [12]
-6.2 Chl OH Thr286 [5] OG1 Val283 [5] Thr286 [5] Phe287 [5]
Serotonin transporter (SLC6), mutant, bound to Br-citalopram, human, 5i74
-8.5 Chl OH Thr264 [4] OG1 Met260 [4] Phe263 [4] Thr264 [4]
-6.2 Chl OH Phe548 [12] O Leu547 [12] Phe548 [12] Phe551 [12]
Serotonin transporter (SLC6), mutant, bound to citalopram and Br-citalopram, human, 5i75
-9.1 Chl OH Phe263 [4] O Met260 [4] Phe263 [4] Thr264 [4]
Chl OH Thr264 [4] OG1
-6.5 Chl OH Thr286 [5] OG1 Val283 [5] Thr286 [5] Phe287 [5]
-6.3 Chl OH Phe548 [12] O Leu547 [12] Phe548 [12]
Antiporters
Mitochondrial ADP/ATP Carrier with carboxyatractyloside, heart, bovine, 1okc
-6.7 Chl OH Ala24 [1] O Ala24 [1]
Mitochondrial ADP/ATP Carrier,  with bound cardiolipins, heart, bovine, 2c3e
-7.3 Chl OH Gly224  [5] O Gly224 [5] Ser227 [5] Tyr228 [5]
-6.5 Arg234 [5] NH2 Chl OH Leu127 [3] Ser179 [4] Arg234 [5]
Chl OH Ser179 [4] OG
-6.3 Chl OH Ala24 [1] O Ala24 [1]
ATP Binding Cassette (ABC) Transporters
P-Glycoprotein, nucleotide-free, inward-facing, mouse, 4q9h
-8.7 His60 [1] NE2 Chl OH His60 [1] Gln191 [3] Gln942 [11]
-8.4 Chl OH Tyr303 [5] OH Tyr303 [5] Gln721 [7]
-6.2 Chl OH Thr765 [8] OG1 Cys713 [7] Thr765 [8]
P-Glycoprotein, ATP-bound, outward-facing, human, 6cOv
-7.4 Chl OH Ser222 [4] OG Ser222 [4] Gly226 [4]
Ser222 [4] OG Chl OH
-7.0 Chl OH Thr845 [9] OG1 Ala841 [9] Thr845 [9]
-6.5 Chl OH Ala987 [9] O Asn839 [9] Ala987 [9]
MRP-1 drug resistance protein, ATP-bound, outward facing, bovine, 6bhu
-9.6 Chl OH Ser446 [3] OG Asp336 [1] Ser446 [3] Gln450 [3]
-7.6 Chl OH Thr378 [2] OG1 Ala374 [2] Thr378 [2] Asn1207 [11]
ABCB10 mitochondrial ABC transporter with bound AMPPC, human, 4ayt
-8.7 Chl OH Ser182 [1] OG Leu178 [1] Ser182 [1] Arg295 [3]
-8.7 Chl OH Ser326  [4] OG Val322  [4] Val325  [4] Ser326  [4]
-8.0 Chl OH Ser181 [1] OG
Ser181 [1] OG Chl OH Ser181 [1] Ser182 [1]
-7.9 Chl OH Ser301  [3] OG Gly297  [3] Ser301  [3]
ABCB10 mitochondrial ABC transporter with bound AMPPC, rod form, human, 4ayx
-8.6 Trp440  [6] NE1 Chl OH Gln299  [3] Trp440  [6]
-8.6 Chl OH Ser182 [1] OG Leu178 [1] Ser181 [1] Ser182 [1]
-8.6 Chl OH Ser182 [1] OG Ser182 [1] Gln299  [3]
-8 Chl OH Ser181 [1] OG Ser181 [1] Gly225  [2]
-7.7 Chl OH Ser326  [4] OG Val322  [4] Val325  [4] Ser326  [4]
ABCB10 mitochondrial ABC transporter with bound AMPPC, plate form, human, 4ayw
-9.5 Chl OH Ser181 [1] OG Ser181 [1] Gly225  [2]
-9.5 Chl OH Ser326  [4] OG Val322  [4] Val325  [4] Ser326  [4]
-8.5 Trp440  [6] NE1 Chl OH Ser185  [1] Gln299  [3] Trp440  [6]
ABCB10 mitochondrial ABC transporter, nucleotide-free rod form, human, 3zdq
-8.4 Chl OH Ser181 [1] OG Ser181 [1] Asn229  [2]
Ser181 [1] OG Chl OH
-8.3 Chl OH Ser182 [1] OG Ser182 [1] Gln299  [3]
-8.3 Trp440  [6] NE1 Chl OH Gln299  [3] Trp440  [6]
Cystic Fibrosis Transmembane conductance regulator (CFTR), Zebra fish, 5tsi
-9.2 Chl OH Leu1114 [11] O Leu1114 [11] Phe1115 [11]
-8.1 Chl OH Ser232 [4] OG Leu228 [4] Ser232 [4]
-7.7 Chl OH Glu871  [7] OE1 Glu871 [7] Tyr927 [8] Leu934 [8]
Chl OH Tyr927 [8] OH
-7.5 Chl OH Phe313  [5] O Ala310 [5] Phe313 [5] Ser314 [5]
-6.9 Arg941 [8] NH1 Chl OH Arg941 [8]
-6.9 Chl OH Thr133 [2] OG1 Gly129 [2] Leu130 [2] Thr133 [2]
-6.5 Chl OH Thr1120 [11] OG1 Val1116 [11] Phe1117 [11] Thr1120 [11]